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2 edition of Superoxide dismutase gene expression in copper deficient rats. found in the catalog.

Superoxide dismutase gene expression in copper deficient rats.

Caroline Joyce

Superoxide dismutase gene expression in copper deficient rats.

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Published by The Author] in [S.l .
Written in English

Edition Notes

Thesis (M. Sc. (Biomedical Sciences)) - University of Ulster, 1992.

The Physical Object
Paginationvi, 117p., tables :
Number of Pages117
ID Numbers
Open LibraryOL21161900M

DIETARY REFERENCE INTAKES TABLE Effect of Increasing Doses of Zinc (Zn) Intake on Copper (Cu) Status Study Subjects Zinc Intake (mg/d) Duration Prasad et al., 1 black man, â 2y 26 y w/sickle cell anemia Greger et al., 14 girls, 12â 14 y (food) 30 d (food) 30 d Burke et al., 5 men, 6 women, 56â 83 y   Superoxide Dismutase (SOD) and its Protection of the Liver. Date: Septem AM Author: Darrell Miller Subject: Superoxide Dismutase (SOD) and its Protection of the Liver SOD consists of enzymes that speed up the break-down or partition/dismutation of the superoxide (O2-) radical into its constituent molecular content Oxygen or hydrogen peroxide. • Sugino N, Hirosawa-Takamori M, Zhong L, Telleria CM, Shiota K and Gibori G (). Hormonal regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase mRNA in the rat corpus luteum: Induction by PRL and placental lactogens. Biology of Reproduction.

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Superoxide dismutase gene expression in copper deficient rats. by Caroline Joyce Download PDF EPUB FB2

Copper/zinc superoxide dismutase-1 (SOD1) was the first gene associated with hereditary ALS (Fig. ).More than mutations have now been identified in the SOD1 gene, accounting for approximately 20% of fALS cases and a further 1% of sALS.

The SOD1 protein normally functions in detoxifying (dismutating) the superoxide radicals (O 2 −) that are a byproduct of normal metabolic processes. Superoxide dismutase (SOD) is a copper- and zinc-containing enzyme that was first isolated from cattle blood (McCord and Fridovich, ).

It promotes the dismutation of two O 2− molecules to H 2 O 2 and O 2 (Fig. SOD helps prevent the buildup of superoxide, which can act as an oxidant by itself, or combine with H 2 O 2 to form the.

The zinc does not participate in this reaction but is essential for the structure of the active site. In addition, the formation of an intrasubunit disulfide bridge stabilizes the enzyme and plays an important role in preventing aggregation of metal-deficient SOD (Getzoff et al., ).Mutations in the gene codifying for SOD1 were linked to familial ALS almost 20 years by: 4.

Over-Expression of Copper/Zinc Superoxide Dismutase in the Median Preoptic Nucleus Attenuates Chronic Angiotensin II-Induced Hypertension in the Rat by John P. Collister 1,*, Mitch Bellrichard 1, Donna Drebes 1, David Nahey 1, Jun Tian 2 and Matthew C. Zimmerman 2Cited by: 3. BackgroundSmall increases in zinc (Zn) consumption above recommended amounts have been shown to reduce copper (Cu) status in experimental animals and humans.

Recently, we have reported that copper chaperone for Cu/Zn superoxide dismutase (CCS) protein level is increased in tissues of overtly Cu-deficient rats and proposed CCS as a novel biomarker of Cu sWeanling male Wistar. We have examined the protein content and gene expression of three superoxide dismutase (SOD) isoenzymes in eight tissues from obese ob/ob mice, particularly placing the focus on extracellular-SOD.

The copper metalloenzyme, superoxide dismutase, the selenoenzyme, glutathione peroxidase, and hepatic ATP were decreased in the copper-deficient rats fed fructose as compared to copper-deficient. MTF-1, a zinc-dependent transcription factor, activates metallothionein gene expression, which can protect cells against oxidative stress.

Zinc is a structural component of the enzyme superoxide dismutase, which promotes the conversion of two superoxide radicals to hydrogen peroxide and molecular by: Copper is an essential trace element that is vital to the health of all living things (humans, plants, animals, and microorganisms).In humans, copper is essential to the proper functioning of organs and metabolic processes.

The human body has complex homeostatic mechanisms which attempt to ensure a constant supply of available copper, while eliminating excess copper whenever this occurs.

Carri MT, Galiazzo F, Ciriolo MR, Rotilio G () Evidence for co-regulation of Cu,Zn superoxide dismutase and metallothionein gene expression in yeast through transcriptional control by copper via the ACE 1 factor.

FEBS Lett – PubMed Google ScholarCited by: Frankel D, Mehindate K, Schipper HM. Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia.

J Cell Physiol. ;–6. PubMed CrossRef Google ScholarCited by: 1. ROSSI L, CIRIOLO MR, MARCHESE E, DE MARTINO A, GIORGI M, ROTILIO G (). Differential decrease of copper content and of copper binding to superoxide dismutase in liver, heart and brain of copper-deficient rats. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol.p.ISSN: X, doi: /bbrc copper-nicotinate complex, cytokines gene expression, fatty liver, hepatoprotective, oxidative stress markers.

Introduction. Non-alcoholic fatty liver disease (NAFLD) is. the most common chronic liver disorder across the world. It has a prevalence of approximately 20% in the general population and up to 95% in people with obesity.

Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation. J Neurosci. - Cited by:   Superoxide dismutase is an endogenous and first-line-of-defense enzyme that eliminates superoxide by catalyzing its dismutation into O 2 and H 2 O 2 (, ).

Historically, most early synthetic antioxidant compounds were originally developed as SOD mimics, especially because the role of ONOO − and its decomposition products in Cited by: Enter search terms. Keep search filters New search.

Advanced search. Due to its early discovery inthe best-studied mutation associated with the familial form of ALS (fALS) is in the gene encoding copper/zinc superoxide dismutase (Cu/Zn SOD, SOD1) (Rosen et al., ). SOD1 is a kDa homodimeric metalloenzyme, found primarily in the nucleus, plasma membrane, and by: gene expression (91) 91 Filter by: Remove filter: Full Text An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase.

Full Text Manganese superoxide dismutase (MnSOD Val-9Ala) gene polymorphism and susceptibility to gastric cancer. Copper-zinc superoxide dismutase (Cu/Zn-SOD) in the liver is less active in copper-deficient rats, whereas other hepatic antioxidant enzymes are unaffected by copper deficiency.

This observation suggests that proper incorporation of copper in Cu/Zn-SOD may be key to preventing lipid by: THE essentiality of copper for animals was reported in in a study showing that it is essential for erythropoiesis in rats fed a milk-based diet (Hart et al.

Erythropoiesis was improved when copper sulfide containing ash was added back to the diet (Hart et al. Reports of copper-deficiency in grazing livestock followed, further substantiating the essentiality of copper (Neal.

@article{osti_, title = {Characterization of the Bacillus stearothermophilus manganese superoxide dismutase gene and its ability to complement copper/zinc superoxide dismutase deficiency in Saccharomyces cerevisiae}, author = {Bowler, C.

and Inze, D. and Van Camp, W. and Kaer, L.V. and Dhaese, P.}, abstractNote = {Recombinant clones containing the manganese superoxide dismutase. Trace Elements in Man and Animals 6 by Lucille S. Hurley,available at Book Depository with free delivery worldwide.

@article{osti_, title = {Protection against hyperoxia by serum from endotoxin treated rats: absence of superoxide dismutase induction}, author = {Berg, J T and Smith, R M}, abstractNote = {Endotoxin greatly reduces lung injury and pleural effusions in adult rats exposed to normobaric hyperoxia (> 98% oxygen for 60 hours).

This study reports that serum from endotoxin treated donor rats. Copper-nicotinate complex (CNC) is a biologically active copper-chelating complex that exhibits superoxide dismutase (SOD)-mimicking activity, anti-inflammatory action in gastric ulcer, and reduction of hepatocellular carcinoma, acts a rheumatoid arthritis treatment, improves skin burns, ameliorates nephrotoxicity resulting from the topical.

Extracellular superoxide dismutase (EC-SOD, or SOD3) is the major extracellular antioxidant enzyme in the lung. To study the biologic role of EC-SOD in hyperoxic-induced pulmonary disease, we created transgenic (Tg) mice that specifically target overexpression of human EC-SOD (hEC-SOD) to alveolar type II and nonciliated bronchial epithelial cells.

Copper-deficient female rats exhibited a greater degree of copper deficiency than males, as assessed by hepatic copper concentration and hepatic copper superoxide dismutase (CuSOD) activity.

However, copper-deficient male rats fed fructose-containing diets exhibited greater growth retardation, anemia, and heart hypertrophy than females. Español. Summary. Copper is an essential cofactor for oxidation-reduction reactions involving copper-containing oxidases.

Copper enzymes regulate various physiologic pathways, such as energy production, iron metabolism, connective tissue maturation, and neurotransmission.

(More information) Copper deficiency can result from malnutrition, malabsorption, or excessive zinc intake and can be. Am J Pathol. Jun;91(3) The lung of the copper-deficient rat. A model for developmental pulmonary emphysema. O'Dell BL, Kilburn KH, McKenzie WN, Thurston RJ.

Abstract. Based on the hypothesis that cross-linked elastin is critical for normal lung structure, lung tissue from copper-deficient rats was studied. Missense mutations in the gene encoding the free radical-scavenging metalloenzyme, copper, zinc superoxide dismutase (SOD1) are responsible for 20% of familial ALS cases (Rosen et al., ).

To date, > mutations have been found in the SOD1 gene, and transgenic mice overexpressing various SOD1 mutants develop an ALS-like phenotype through a Cited by: The endogenous antioxidant enzyme that is responsible for neutralising Superoxide free radicals are known as Superoxide Dismutase (SOD).

There are 3 main types of Superoxide Dismutase enyzymes, each found in a specific location. Each type of SOD is encoded by. Scientifically proven copper peptides developed by biochemist Dr. Loren Pickart are essential to understanding how to reverse the diseases of aging | Discover new genetic research on COPD, Emphysema, cancer, healing, cosmetic products, and the science behind copper peptides - Call Skin Biology   The expression of MSD3 through MSD5, encoding various isoforms of the MnSODs, is up-regulated severalfold in Mn-deficient cells, but neither expression nor activity of the plastid Fe-containing superoxide dismutase is changed, which contrasts with the dramatically increased MSD3 expression and plastid MnSOD activity in Fe-deficient cells.

This book is the published proceedings of the Sixth International Symposium on Trace Element Metabolism in Man and Animals. The Symposium was held at the Asilomar Conference Center in Pacific Grove, California, U.S.A. from May 31 through June 5, The decision to hold TEMA-6. Reactive oxygen species (ROS) are products of normal cellular metabolism and derive from various sources in different cellular compartments.

Oxidative stress resultant from imbalance between ROS generation and antioxidant defense mechanisms is important in pathogenesis of cardiovascular diseases, such as hypertension, heart failure, atherosclerosis, diabetes, and cardiac Cited by: Interest in relationship between diet and ageing is growing.

Research has shown that dietary calorie restriction and some antioxidants extend lifespan in various ageing models.

On the one hand, oxygen is essential to aerobic organisms because it is a final electron acceptor in mitochondria. On the other hand, oxygen is harmful because it can continuously generate reactive oxygen species (ROS Cited by: This chapter reviews the changes in cellular physiology that follow contact with host cells and the impact of these changes on the host-pathogen interaction.

The focus is on Candida albicans, for the simple reason that the vast majority of the published research is on this species. The chapter focuses on the interaction between Candida cells and the most important and relevant mammalian cell Cited by: 1.

Research based supplements for improving eyesight - posted in Supplements: These are just a collection of statements and studies I found while researching alphaantitrypsin deficiency (A1AT) and it's relationship to decreased levels of glutathione.

Doing this, I found there's also a relationship b/w A1AT, corneal problems and antioxidants. I've also been reading into improving conditions 5/5(1). Dopamine (DA) is a free radical scavenger that attenuates apoptosis. We studied the effects of normal saline (NS) and DA on diaphragm apoptotic protein expression following 60 min of inspiratory resistance loading in rats.

We tested for 27 apoptotic-related proteins and found 12 in the diaphragm. Of the 12 proteins, superoxide dismutase copper zinc (SOD [CuZn]) and proprioceptive event related Cited by: 3. Extracellular superoxide dismutase (EC-SOD, or SOD3) is the major extracellular antioxidant enzyme in the lung.

To study the biologic role of EC-SOD in hyperoxic-induced pulmonary disease, we created transgenic (Tg) mice that specifically target overexpression of human EC-SOD (hEC-SOD) to alveolar type II and nonciliated bronchial epithelial by:   Zinc deficiency, like chronic copper overdosage, leads to enhanced liver microsomal lipid peroxidation in rats (Sullivan et al., ).

Copper binds to sulfhydryl moieties and may oxidize them, whereas zinc binds and protects against oxidation. Both copper and zinc are active centre atoms of cytoplasmic superoxide dismutase. The health benefits of green tea for a wide variety of ailments, including different types of cancer, heart disease, and liver disease, were reported.

Many of these beneficial effects of green tea are related to its catechin, particularly (-)-epigallocatechingallate, content. There is evidence from in vitro and animal studies on the underlying mechanisms of green tea catechins and their. Brown DR, Besinger A () Prion protein expression and superoxide dismutase activity.

Biochem J– [] Wong BS, Pan T, Liu T, Li RL, Gambetti P, Sy MS () Differential contribution of superoxide dismutase activity by prion protein in vivo. Biochem Biophys Res Commun– []Cited by:   The process of neuronal degeneration in motor neurone disease is complex.

Several genetic alterations may be involved in motor neurone injury in familial amyotrophic lateral sclerosis, less is known about the genetic and environmental factors involved in the commoner sporadic form of the disease.

Most is known about the mechanisms of motor neurone degeneration in the subtype of Cited by: